Following the great success of the 2025 event, the University of Sheffield, LUMICKS, and additional sponsors proudly present the second UK-Ireland symposium focusing on single-molecule research! Featuring exciting keynotes, talks, posters and discussions, the SMBIO 2026 UK & IRELAND 2-day event aims to bring together scientists interested in single-molecule approaches to biology from all over the UK and Ireland to share their research, connect, and exchange ideas and experiences.